4-Bromophenylboronic acid, CAS 5467-74-3, is an aromatic boronic acid building block with both a boronic acid group and a para-bromine substituent on the benzene ring. Its molecular formula is C6H6BBrO2, and its calculated molecular weight is approximately 200.82 g/mol. I identify it as a useful intermediate for Suzuki–Miyaura coupling and other organic synthesis routes where controlled carbon–carbon bond formation or further functionalization is required.
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For B2B procurement, the most important considerations are chemical identity, assay, water content, appearance, packaging, batch documentation, and shipment conditions. The material is generally supplied as a solid, often described as white to off-white, but the exact appearance and specification should be confirmed against the supplier’s current certificate of analysis. At Maison Chemical, we support buyers by reviewing the intended application, required grade, quantity, documentation, and delivery conditions before quotation.
4-Bromophenylboronic acid contains a boronic acid group, written as –B(OH)2, attached directly to an aromatic ring. The bromine atom is positioned para to the boronic acid group, meaning the two substituents occupy opposite positions on the benzene ring. This defined substitution pattern gives the compound two useful synthetic handles in one relatively small molecule.
The boronic acid group can participate in palladium-catalyzed Suzuki–Miyaura coupling with suitable aryl or vinyl halides. The aryl bromide on the same molecule can also remain available for later transformation, depending on the reaction system and selectivity requirements. This combination makes 4-Bromophenylboronic acid valuable when a synthetic route needs a functionalized aromatic intermediate rather than a simple monosubstituted building block.
| Parameter | Information for buyer review |
|---|---|
| Product name | 4-Bromophenylboronic acid |
| CAS number | 5467-74-3 |
| Alternative names | 4-Bromobenzeneboronic acid; (4-bromophenyl)boronic acid |
| Molecular formula | C6H6BBrO2 |
| Calculated molecular weight | Approximately 200.82 g/mol |
| Functional groups | Aryl boronic acid and aryl bromide |
The molecular weight shown above is a calculated chemical value, not a batch test result. Buyers should use the CAS number, structure, and formula together when checking an internal database or comparing supplier quotations. If a purchasing system requires a specific naming convention, I recommend recording both the systematic name and the CAS number to reduce the risk of selecting a positional isomer.
As an aromatic boronic acid, this material should be evaluated for sensitivity to moisture, oxidation, and prolonged exposure to unsuitable storage conditions. Boronic acids can participate in equilibria with water and may show behavior that depends on solvent, pH, temperature, and concentration. For this reason, I recommend following the supplier’s safety data sheet and batch-specific handling instructions rather than relying on a generic storage assumption.
In practical laboratory and manufacturing work, the material should be kept in a tightly closed container and protected from contamination. A cool, dry storage area is commonly considered appropriate when consistent with the applicable SDS and local requirements. Buyers should also check whether the supplier specifies a temperature range, inert-gas recommendation, retest period, or special transport precaution for the selected packaging format.
Reaction performance may be influenced by assay, water content, particle condition, catalyst choice, base, solvent, and the identity of the coupling partner. A material that meets a nominal purity target may still require process validation in the buyer’s own reaction system. We therefore treat the certificate of analysis, analytical method, and intended synthesis route as connected procurement requirements rather than separate administrative details.
The primary use of 4-Bromophenylboronic acid is as an aryl boronic acid reagent in cross-coupling chemistry. Under a suitable catalytic system, its boronic acid group can react with an aryl or vinyl halide to form a new carbon–carbon bond. The para-bromo substituent may be retained in the coupled product, allowing the product to undergo a subsequent transformation in a multi-step synthesis.
This sequential functionality is particularly relevant to medicinal chemistry, pharmaceutical intermediate development, agrochemical research, and specialty materials synthesis. The correct route depends on chemoselectivity, catalyst compatibility, and the stability of the desired intermediate. I recommend that process chemists confirm whether the aryl bromide should remain intact or be consumed during the planned reaction sequence before selecting this compound.
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Aryl boronic acids can also serve as intermediates in oxidation and related functional-group transformations. For example, oxidation of the boronic acid functionality may be used to access a phenolic derivative under an appropriate method. The actual outcome depends on reagents and reaction conditions, so the compound should be treated as a synthesis intermediate rather than as a universal reagent for every aromatic conversion.
Because the molecule contains two chemically relevant positions, it can be used in route scouting and building-block libraries. Its value is often greatest when a project needs a defined para-substituted aromatic framework and plans additional coupling, derivatization, or structure–activity relationship work. It is not normally purchased as a final-use ingredient without further chemical conversion.
For routine purchasing, I suggest requesting a specification that covers identity, assay or purity, appearance, water content when relevant, and any known impurities important to the reaction. A buyer may request a purity target such as ≥98%, but this should be treated as a purchasing requirement to be confirmed by the supplier, not as an automatic specification for every available batch. The analytical method, such as HPLC, NMR, or another agreed method, should also be identified where the result is critical to process release.
Documentation may include a certificate of analysis, safety data sheet, product specification, batch or lot number, manufacturing date, and retest or review information where applicable. For regulated or quality-sensitive projects, buyers should state documentation needs before order confirmation. I also recommend confirming whether the reported assay is corrected for water, residual solvent, or another basis, because different reporting conventions can affect comparisons between suppliers.
Packaging should match both the quantity and the material’s handling needs. Smaller research quantities may be supplied in sealed laboratory containers, while larger orders may require an agreed inner liner, moisture-protective closure, or transport configuration. The buyer should verify net weight, container count, labeling, and whether the package can be used directly in the receiving facility.
Lead time and minimum order quantity are normally dependent on stock status, production scheduling, packaging format, destination, and documentation requirements. Rather than quoting a universal delivery period, we review these variables with the buyer before issuing a commercial offer. For international shipments, the purchaser should also confirm import requirements, transport classification, customs documents, and any local restrictions before placing the order.
A suitable supplier should be able to match the exact CAS number and provide traceable batch information. I recommend comparing the requested specification with the supplier’s actual certificate format, including the test items, acceptance limits, analytical basis, and release date. A low unit price is less useful if the material requires additional qualification, arrives in unsuitable packaging, or lacks the documents needed for internal approval.
At Maison Chemical, we approach 4-Bromophenylboronic acid procurement as a technical sourcing discussion. We can review the intended use, required quantity, purity level, packaging preference, destination, and documentation package before recommending a supply option. Any commercial specification, availability statement, or delivery estimate should be confirmed for the individual order and batch.
4-Bromophenylboronic acid CAS 5467-74-3 is a versatile aromatic intermediate for synthetic routes requiring a boronic acid function together with a para-bromo substituent. Its main procurement value is the combination of defined chemical identity, dual synthetic functionality, and suitability for further molecular construction. However, reaction suitability and material performance must be confirmed against the buyer’s process conditions and quality requirements.
For the next step, prepare the target quantity, required purity, application or reaction type, packaging preference, destination, and documentation needs. Send these details to Maison Chemical for a focused review of specification, availability, and commercial supply conditions. We can then help you evaluate whether this product is the appropriate grade for your laboratory, pilot, or manufacturing program.
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