3,4-Difluoro-2-methoxyphenylboronic acid CAS 905583-06-4 is a specialty aromatic boronic acid used primarily as a synthetic building block in pharmaceutical research, medicinal chemistry, and fine-chemical development. Its main value comes from the boronic acid group, which can participate in palladium-catalyzed Suzuki–Miyaura coupling with suitable aryl or heteroaryl halides to form biaryl compounds. The difluoro and methoxy substituents provide a defined electronic and steric pattern that researchers may use when designing or optimizing substituted aromatic molecules.
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At Maison Chemical, I present this material as a research and manufacturing intermediate rather than as a finished pharmaceutical ingredient. Its suitability depends on the target structure, reaction conditions, required quality grade, analytical documentation, and intended use. Buyers should therefore confirm identity, assay, water content, impurity limits, packaging, and regulatory requirements before placing a production order.
The most established use of this compound is as an arylboronic acid coupling partner. In a Suzuki–Miyaura reaction, the boronic acid functionality is commonly used to connect the substituted aromatic ring to another carbon-based fragment, especially an aryl, heteroaryl, or vinyl halide. This makes the compound useful for constructing more complex molecular architectures during discovery and process-development work.
The molecule contains two fluorine atoms and one methoxy group on the aromatic ring. These substituents can influence lipophilicity, electronic distribution, conformation, and the reactivity of the ring in a final compound, although the actual effect must be evaluated for each molecular scaffold. Researchers may select this building block when the 3,4-difluoro-2-methoxy substitution pattern is specifically required in a target or analog series.
Pharmaceutical research teams may use this compound to prepare intermediate structures, analog libraries, and lead-optimization candidates. The boronic acid group provides a practical point for late-stage or convergent bond formation, while the fluorinated methoxy-substituted ring can help investigate structure–activity relationships. These are development uses, not evidence that the material itself has therapeutic activity or is approved for medical use.
In a medicinal chemistry program, the compound may be combined with different halogenated or heterocyclic partners to generate a series of related molecules. Comparing those products can help researchers study how aromatic substitution affects biological assay results, physicochemical behavior, or metabolic stability. Any biological performance must be established through the customer’s own validated testing and cannot be inferred from the building block alone.
Fine-chemical manufacturers can use 3,4-difluoro-2-methoxyphenylboronic acid as an intermediate for custom synthesis projects. It may be relevant to the preparation of advanced aromatic fragments, reference compounds, screening molecules, or route-development samples. The compound can also serve as a starting material when a project requires a specific substituted biaryl or heteroaryl structure.
For scale-up, the reaction route should be assessed rather than assuming that a literature-scale transformation will transfer directly to manufacturing. Important variables may include catalyst selection, base compatibility, solvent choice, reaction concentration, phase behavior, and the purification strategy. A small-scale feasibility test and analytical review are prudent before committing to larger quantities.
The defining functional group is the arylboronic acid moiety, which is commonly selected for carbon–carbon bond construction. The two fluorine substituents and methoxy group remain part of the aromatic fragment after coupling, allowing the researcher to introduce a pre-defined substitution pattern in one synthetic step. This combination can be valuable when a target molecule requires both a coupling handle and specific ring substitution.
| Property or identifier | Information | Why it matters |
|---|---|---|
| Product name | 3,4-Difluoro-2-methoxyphenylboronic acid | Defines the substituted aromatic boronic acid building block |
| CAS Registry Number | 905583-06-4 | Supports product identification during sourcing and documentation review |
| Molecular formula | C7H7BF2O3 | Useful for stoichiometric calculations and analytical comparison |
| Approximate molecular weight | 187.94 g/mol | Supports molar conversion and reaction planning |
The molecular weight shown above is a calculated reference value based on the stated molecular formula, not a batch-specific analytical result. Commercial material may contain water, residual solvents, or trace impurities depending on manufacturing and packaging history. For that reason, I recommend using the batch-specific certificate of analysis for final weighing, assay correction, and release decisions.
In early-stage synthesis, researchers may screen this building block with several aryl or heteroaryl halides to identify a productive coupling route. A screening plan can compare catalyst systems, bases, solvents, temperature profiles, and reaction times. The purpose is to determine whether the selected boronic acid gives acceptable conversion and a manageable impurity profile under the project’s conditions.
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Reaction performance is not guaranteed by the name or CAS number alone. Boronic acids can show different behavior depending on substrate structure, concentration, moisture exposure, catalyst system, and work-up conditions. I therefore encourage customers to evaluate the material using their own reaction controls and analytical methods before using it as a critical route input.
Once a coupling route is established, the compound may be used to prepare an advanced intermediate or a small series of analogs. This is particularly relevant when the same difluoro-methoxyphenyl fragment appears in multiple target structures. Using a consistent starting material can simplify route comparison, material planning, and analytical tracking across a development program.
For production planning, buyers should distinguish between a laboratory sample, a development quantity, and a manufacturing quantity. These stages may require different packaging, release testing, lead-time planning, and documentation. A supplier that can discuss the intended scale early may help reduce avoidable changes later in the project.
Before purchasing, I recommend confirming the exact product identity, molecular formula, molecular weight, appearance, assay method, and impurity profile. Buyers should also ask whether the quoted specification is suitable for research use, process development, or a more controlled manufacturing application. The correct requirement depends on the customer’s route, internal quality system, and downstream regulatory obligations.
These checks are more useful than selecting a supplier only by the lowest quoted price. A lower unit price may not represent lower total cost if the buyer later needs additional testing, repacking, replacement material, or route troubleshooting. Clear specifications at the inquiry stage help both sides assess whether the material is appropriate for the intended application.
When I evaluate an inquiry for Maison Chemical, I first focus on the technical and commercial details needed to provide a responsible quotation. These typically include the requested quantity, target specification, intended application, packaging preference, destination, and required delivery window. If the customer is scaling a route, I also consider whether a sample, development batch, or larger production quantity is the appropriate starting point.
A suitable supplier should be able to communicate what is known, what requires confirmation, and what documentation can be provided with the shipment. Buyers should be cautious about unsupported claims involving guaranteed reaction performance, universal pharmaceutical suitability, or fixed delivery dates without a confirmed production plan. In specialty chemicals, transparent qualification is usually more valuable than an absolute promise.
Maison Chemical supplies specialty chemical intermediates for research, development, and commercial sourcing discussions. For 3,4-difluoro-2-methoxyphenylboronic acid CAS 905583-06-4, I can help customers review the required specification, quantity, packaging, documentation, and delivery destination before an order is finalized. The exact availability, batch information, and lead time should be confirmed against the current production and inventory position.
I can also support a structured inquiry by reviewing whether the customer needs a small evaluation quantity or a larger project supply. This distinction helps align the quotation with practical requirements such as sample approval, repeatability, shipping conditions, and batch documentation. Final suitability remains the responsibility of the customer’s technical and quality teams.
3,4-Difluoro-2-methoxyphenylboronic acid CAS 905583-06-4 is mainly used as a substituted arylboronic acid building block for Suzuki–Miyaura coupling and related synthetic research. Its value lies in combining a reactive boronic acid handle with a defined 3,4-difluoro-2-methoxy aromatic fragment. It may support pharmaceutical discovery, medicinal chemistry, fine-chemical synthesis, intermediate production, and custom route development, but it is not itself a finished drug or proof of biological activity.
The practical next step is to match the material specification to the intended reaction and scale. Contact Maison Chemical with your required quantity, purity target, packaging, destination, and documentation needs, and I can help you review the appropriate supply option for your project.
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