1-Methyl-4-pyrazole boronic acid pinacol ester, identified by CAS 761446-44-0, is a boronic ester building block used primarily in organic synthesis and pharmaceutical intermediate development. I classify it as a heteroaryl boronic acid pinacol ester because it combines a methyl-substituted pyrazole ring with a pinacol-protected boron group. Its principal value is its participation in palladium-catalyzed Suzuki–Miyaura coupling, where the pyrazole fragment can be introduced into more complex molecules. The molecular formula is commonly represented as C10H17BN2O2, with a calculated molecular weight of approximately 208.07 g/mol.
The compound is a protected boronic acid derivative of 1-methylpyrazole. The boronic ester group is attached at the 4-position of the pyrazole ring, while the N-1 position carries a methyl group. The pinacol ester form is used instead of the corresponding free boronic acid because protected boron reagents are often more convenient to handle, weigh, store, and use in synthetic reaction planning.
| Property | Information |
|---|---|
| Product name | 1-Methyl-4-pyrazole boronic acid pinacol ester |
| CAS number | 761446-44-0 |
| Common chemical class | Heteroaryl boronic ester |
| Molecular formula | C10H17BN2O2 |
| Approximate molecular weight | 208.07 g/mol |
| Key reactive group | Pyrazole-substituted boronic pinacol ester |
I recommend treating the values above as identity and reference data rather than a substitute for a product-specific certificate of analysis. Appearance, assay, water content, residual solvents, and chromatographic purity can vary by manufacturing batch and specification. Buyers should request current technical documentation before approving the material for a regulated or scale-up project.
The main function of CAS 761446-44-0 is to provide a 1-methylpyrazol-4-yl fragment during carbon–carbon bond formation. In a typical Suzuki–Miyaura coupling, the boronic ester reacts with an appropriate aryl or heteroaryl halide under a suitable catalyst, base, solvent, and temperature system. The exact reaction performance depends on the coupling partner and process conditions, so I do not recommend assuming that one standard procedure will apply to every substrate.
Pyrazole rings occur in many medicinal chemistry programs because their nitrogen-containing structure can contribute to molecular recognition and property optimization. This boronic ester can help chemists introduce a methylated pyrazole unit into lead compounds, advanced intermediates, and structure–activity relationship libraries. Its use does not by itself indicate a specific therapeutic application; the final use depends on the complete molecular structure and the buyer’s development program.
At laboratory scale, the product can support parallel synthesis, route scouting, and late-stage diversification of aromatic or heteroaromatic compounds. At process-development scale, buyers generally evaluate not only reaction conversion but also impurity profiles, isolation behavior, reproducibility, and supply continuity. I can support these evaluations by providing batch documentation and discussing the intended synthesis before commercial supply is finalized.
The compound is not a finished active pharmaceutical ingredient, and it should not be represented as one. It is a research and manufacturing input that requires qualified handling, documented testing, and a synthesis-specific risk assessment. The appropriate use level may range from gram-scale discovery work to larger quantities for process development, subject to project requirements and supply availability.
When I discuss this product with B2B buyers, I distinguish between material options by specification and service requirement rather than by changing the core CAS number. The same chemical identity may be supplied in different pack sizes, purity targets, documentation packages, or delivery arrangements. A buyer may request a research-grade lot for early screening, while a process team may require tighter impurity control and consistent batch-to-batch data.
A stated purity target should always be confirmed against the current lot documentation. For example, a supplier may offer a specification of 98% or higher by an agreed analytical method, but I would not present that as a guaranteed result without the relevant batch certificate. Analytical method, reporting basis, and impurity limits should be aligned before purchase.
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Important purchasing specifications can include assay or chromatographic purity, water content, residual solvents, elemental impurities, appearance, and identification data. Because boronic esters can be sensitive to unsuitable moisture or storage conditions, I advise buyers to review the supplier’s recommended packaging and storage instructions before opening the material. The product should be handled according to its safety data sheet and the buyer’s laboratory or plant procedures.
Useful technical questions include whether the material is supplied as a solid, how the batch is identified, which analytical methods are used, and whether the packaging protects the product from environmental exposure. I also recommend checking whether the required quantity can be supplied from one batch when process consistency is important. These checks are more reliable than selecting a supplier only by catalog price.
First, I suggest confirming the CAS number, molecular structure, formula, and molecular weight against the project specification. Next, request a current certificate of analysis showing the lot number, test results, analytical method, and release status. If the material will enter a regulated development workflow, ask in advance about traceability, change notification, retained samples, and document revision control.
A dependable supplier should communicate whether the material is in stock, produced to order, or subject to a new manufacturing campaign. Lead time should be quoted for the requested quantity rather than copied from a general catalog listing. I also recommend confirming the minimum order quantity, available pack sizes, export documentation, shipping conditions, and the process for handling technical questions.
The best supplier is not necessarily the one offering the lowest initial unit price. A slightly different impurity profile may affect catalyst loading, purification, yield, or downstream quality, so the material should be evaluated in the buyer’s actual route. For scale-up, ask whether future batches can be manufactured against comparable specifications and whether a representative sample can be reviewed before a larger order.
At Maison Chemical, I support customers seeking 1-Methyl-4-pyrazole boronic acid pinacol ester CAS 761446-44-0 for pharmaceutical intermediate and specialty chemical applications. I can help clarify product identity, intended use, requested quantity, packaging, documentation, and delivery requirements before quotation. This approach allows me to distinguish a laboratory trial from a process-supply request and to recommend an appropriate commercial path.
Our support can include product specification review, batch documentation coordination, packaging discussion, export order communication, and supply planning based on the buyer’s project schedule. I do not assume that every application requires the same purity, quantity, or documentation package. Instead, I encourage buyers to provide their target quantity, destination country, required documents, and any internal specification so that the quotation can be prepared accurately.
1-Methyl-4-pyrazole boronic acid pinacol ester CAS 761446-44-0 is a useful boron-containing intermediate for introducing a 1-methylpyrazole group into more complex molecules. It is particularly relevant to pharmaceutical research, heterocyclic synthesis, custom manufacturing, and process chemistry where controlled cross-coupling is part of the route. Its suitability must still be confirmed through the buyer’s reaction evaluation, specification review, and safety procedures.
As the next step, I recommend sending Maison Chemical the required quantity, target purity, delivery destination, application stage, and documentation requirements. I can then help confirm available material, provide the relevant technical documents, and discuss a supply plan appropriate for laboratory, development, or commercial procurement. For a quotation or technical discussion, contact Maison Chemical with the product name and CAS 761446-44-0 so that I can respond to the inquiry efficiently.
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